摘要目的：对益气逐瘀法及其组方参元益气活血胶囊（SYYQ）既往研究工作进行回顾、归纳、分析、总结。方法：以参元丹、参元丹胶囊、参元益气活血胶囊、益气逐瘀法为关键词，电子检索Pubmed、Embase、Web of Science、VIP、CBM、CNKI、万方数据库等中外生物医学数据库，检索年限均为建库起至2018年7月20日，共检索出83篇相关文献，经筛查删除重复及实际内容无关文献，共纳入42篇文献，通过文献研读，对SYYQ的基础和临床研究内容进行归纳、分析、总结。结果：SYYQ在干预缺血性心脏病方面有较丰富的基础工作，临床方面也进行了较多的疗效观察。结论：SYYQ治疗冠心病不稳定性心绞痛安全有效，在冠心病缺血心肌保护方面有较丰富的基础研究成果，应进一步深入研究。
关键词益气逐瘀法；参元益气活血胶囊；冠心病；心肌保护；药理作用机制
Progress of Basic and Clinical Research on the Treatment of Coronary Heart Disease by Replenishing Qi and Removing Blood Stasis
Niu Qian1，Xing Wenlong2，Liu Hongxu2
（1 Beijing Hospital of Traditional Chinese Medicine，Capital Medical University，Beijing 100010，China； 2 Beijing University of Chinese Medicine，Beijing 100029，China）
AbstractObjective：To review，summarize，analyze and conclude previous research work of replenishing qi and removing blood stasis method and its prescription Shenyuan Yiqi Huoxue Capsule （SYYQ）.Methods：The keywords of Shenyuan Dan，Shenyuandan capsule，and Shenyuan Yiqi Huoxue capsule，replenishing qi and removing blood stasis method were used to electronically search in Chinese and foreign biomedical databases such as PubMed，Embase，Web of Science，VIP，CBM，CNKI，Wanfang database，etc.The search period was from establishment to July 20th，2018.A total of 83 related documents were retrieved.After screening and deleting the duplicate and contentindependent documents，a total of 42 articles were included.Through literature research，the contents of basis and clinical study of SYYQ were summarized，analyzed and concluded.Results：SYYQ had abundant basic work in the intervention of ischemic heart disease and had a lot of clinical efficacy observation.Conclusion：SYYQ is safe and effective in the treatment of unstable angina pectoris of coronary heart disease.It has abundant basic research achievements in the myocardial protection of ischemia of coronary heart disease and should be further studied.
Key WordsMethod of benefiting qi and removing blood stasis； Shenyuan Yiqi Huoxue capsule； Coronary heart disease （CHD）； Myocardial protection； Pharmacological action mechanism
中圖分类号：R242；R256文献标识码：Adoi：10.3969/j.issn.1673-7202.2018.08.001
参元丹、参元丹胶囊及参元益气活血胶囊以下共称参元益气活血胶囊（SYYQ）（京药制字Z20053327）是首都医科大学附属北京中医医院刘红旭教授上个世纪80年代针对冠心病不稳定型心绞痛（UA）发病特点创制的院内制剂。UA属中医学“胸痹心痛”范畴[1]，以气虚血瘀证最为常见[23]。SYYQ以益气逐瘀为法，全方以黄芪、党参、土鳖虫、水蛭、丹参、玄参、延胡索等为主要组成，共奏益气养阴、破血逐瘀、通络止痛之功效。SYYQ自创制至今20余年的临床应用中，取得良好的疗效。同时，其在临床疗效观察、扩展应用、基础药理作用及作用机制等方面取得较丰富的研究成果。
本文将分别从基础研究、临床观察研究及中医理论研究等方面对SYYQ既往的研究进行综述。